Synthesis of Phosphocreatine by Enzymes from Heart and Skeletal Muscle


THE transfer of phosphate from high-energy phosphate compounds of glycolytic origin (such as phosphoglycerylphosphate and enol-phosphopyruvate) to creatine has been considered possible only through the adenylic nucleotides1. Direct proof of this has been given so far only for enol-phosphopyruvate2. In the case of the acyl-phosphate, examination of thermodynamic data3 shows that a direct transphosphorylation from phosphoglyceryl phosphate to creatine is possible and that an equilibrium constant of about 10 might be expected.


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