[Mutual disposition of nucleosomes and exons differs from common genome pattern at DNA segments containing periodic nucleotide sequences].

Abstract

The correlation was observed between DNA segments characterized by periodic patterns of nucleotides and nucleosome DNA binding sites predicted by the profiles of local DNA flexibility. Exons of human type I and VII collagen genes loci have been chosen as a sample set of periodic DNA segments. It was pointed that short periodic exons coding fibrillar part of these proteins are localized near borders of the DNA sequence that binds the histone core. One of the borders of exon and of this sequence coincide as a rule. In non-fibrillar parts of collagen genes exons (longer on average) dispose, in contrast, in any place of the DNA sequence bound to the nucleosome core.

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