We reported a case of partial seizures following aseptic meningoencephalitis. A 2-year-10-month-old boy was admitted to our hospital because of generalized seizures with fever. He had no history of previous seizures and had been well until 8 days before admission. He had been given a 4th DPT (diphtheria, tetanus toxoid and pertussis) vaccine 9 days before admission, and had developed fever and exanthema on the trunk the following day. Both fever and exanthema recurred repeatedly thereafter. After admission, he suffered from generalized seizures without fever and many kinds of partial seizures with psychiatric symptom. Despite administration of several antiepileptic drugs, these seizures persisted for one and half months, occurring 5 to 18 times a day. Thirty-six days after admission, MRI showed multiple dark areas on T1-weighted images and bright areas on T2-weighted images in the bilateral frontal area. We considered these to be due to cerebral vasculitis associated with aseptic meningitis. The patient's seizures were finally controlled by zonisamide administration. At the same time, fever went down. He has since shown normal development without seizures for 18 months.
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